Protein Details: voltage-gated potassium channel KAT2

Protein ID

ICDB_Pro_0918

Protein Name

voltage-gated potassium channel KAT2

Gene Name

KAT2; At4g18290; T9A21.140

Organism

Arabidopsis thaliana (Mouse-ear cress)

Length

697 amino acids

AlphaFoldDB

AF-Q38849-F1-model_v4.pdb

Function

Highly selective inward-rectifying potassium channel. This voltage-dependent channel could mediate long-term potassium influx into guard cells leading to stomatal opening. Assuming opened or closed conformations in response to the voltage difference across the membrane; the channel is activated by hyperpolarization. The channel activity is enhanced upon external acidification

Sequence

MSISCTRNFFKRFCVEEYNMDTFKHSSFLSADLLPSLGARINQSTKLRKHIISPFDPRFRGWEMWLVILVIYSAWICPFEFAFITYKKDALFIIDNIVNGFFAIDIILTFFVAYLDSHSYLLVDKPKKIAIRYLSTWFAFDVCSTAPFQSLSLLFKYNGSEIGFRVLSMLRLWRLRRVSSLFARLEKDIRFNYFWTRCTKLISVTLFAVHCAGCFAYLIADQYHDPTKTWIGAVYPNFKETSVWSRYVTALYWSITTLTTTGYGDLHAENPREMLFFVFFMLFNLGFTSYLIGNMTNLVVHWTSRTRNFRDTVRAASEFASRNQLPPNIQDQMLSHICLKFKTEGLKQQEALNGLPKAIRSSIANYLFFPIVQNVYLFHGVSRNFLFQLVSDIDAEYFPPREDVILQNEAPTDLYILVSGAVDFTVYVGEEDQVQGKAVVGDAFGEIGVLCYTPQPFTVRTTELSQILRISKKSLMSAMRAHVEDGRVIMNNLFMKLRGQQSIAIDDPNSEPESLLKEWLVGGSKTGEGNASDQGHGHKYLQLHDSENIDMGSTEWRDSRRSGYGETKRVREHTIEIEEGEKPNKEFDGKGCSDADLTSFEFHSQEAYPYCRSNIQIKQHEAAKPKDKRVTIHLKSRDKDLSKLIILPASIEELLRLAGEKFGYSFTKVTNAENAEIDDEDVIRDGDHLYILINENS

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

377..496

Disease

Location

Expressed in guard cells of hypocotyls; stems leaves and petioles. Detected also in the phloem of minor veins and in flower at a lower level.

DOI ID

10.1074/jbc.m007303200; 10.1038/47134; 10.1111/tpj.13415; 10.1104/pp.126.4.1646; 10.1105/tpc.16.01050

RefSeq

NP_001329801.1; NP_193563.3